Table 2 Motor impairment of heterozygous mice transgenic for human mutant A53T α-synuclein following intracerebral injection of brain extracts from Parkinson’s disease (PD)
Human brain extract | Age at death | Mice injected | Mice with motor impairment | Survival (days) | SD | Survivors to 18 Mo | Survivors with assembled α-synclein |
|---|---|---|---|---|---|---|---|
(1) PD | 76 | 3 | 0 | – | – | 3 | 2 |
(2) PD | 83 | 4 | 4 | 288 | 79 | – | – |
(3) PD | 92 | 3 | 1 | 265 | – | 2 | 1 |
(4) PD | 68 | 3 | 1 | 335 | – | 2 | 1 |
(5) PD | 74 | 4 | 1 | – | – | 3 | 1 |