Table 1 Motor impairment of heterozygous mice transgenic for human mutant A53T α-synuclein following intracerebral injection of brain extracts from multiple system atrophy (MSA)
Human brain extract | Age at death | Mice injected | Mice with motor impairment | Survival (days) | SD |
|---|---|---|---|---|---|
(1) MSA-P | 68 | 10 | 10 | 168 | 21 |
(2) MSA-P | 75 | 2 | 2 | 181 | 12 |
(3) MSA-P | 82 | 3 | 3 | 166 | 28 |
(4) MSA-P | 65 | 4 | 4 | 166 | 20 |
(5) MSA-P | 83 | 4 | 4 | 168 | 19 |
(6) MSA-C | 69 | 3 | 3 | 174 | 4 |
(7) MSA-C | 60 | 4 | 4 | 152 | 23 |