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Table 1 Methylation (sub)classa distribution of cerebellar and supratentorial WHO grade IV gliomas

From: Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

methylation (sub)classa supratentorial Percent cerebellar Percent
n = 522 n = 42
GBM G34 37 7 0 0
GBM MES 127 24 4 10
GBM MID 23 4 11 26
GBM MYCN 18 3 3 7
GBM RTK I 72 14 8 19
GBM RTK II 171 33 2 5
GBM RTK III 9 2 1 2
DMG K27b 33 6 7 17
A IDHb 32 6 6 14
  1. GBM IDH mut glioblastoma IDH mutant, DMG K27 diffuse midline glioma H3 K27 M mutant, GBM G34 glioblastoma IDH wildtype subclass H3 G34 mutant, GBM MYCN glioblastoma IDH wildtype subclass MYCN, GBM MES glioblastoma IDH wildtype subclass MES, GBM RTK I/II/III glioblastoma IDH wildtype subclass(es) RTK I/III/III, GBM MID glioblastoma IDH wildtype subclass midline, A IDH IDH mutant glioma subclass astrocytoma or high grade astrocytoma
  2. a Methylation class is defined as group of tumors with the same classifier diagnosis (= epigenetic subgroup) which was allotted to a tumor sample with a classifier score above 0.9
  3. b Frequencies of these tumors may be biased depending on the supplier diagnosis, the date of diagnosis and the availability and application of antibodies or sequencing methods detecting IDH and histone mutations