Fig. 1
From: Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities
Methylation-based t-SNE distribution of 86 tumors designated cerebellar glioblastoma and 12 established reference methylation clusters comprising a reference cohort of 707 gliomas. Reference cases are indicated as colored dots with each color representing one reference methylation cluster. Tumors of the study cohort are indicated as black-rimmed circles. The table shows the distribution of tumors in the cerebellar study cohort among the reference methylation clusters. cGBM – cerebellar glioblastoma, meth. Cluster – methylation cluster, # - number of tumors in the cGBM cohort, HGNET BCOR – high grade neuroepithelial tumor with BCOR alteration, DMG K27 – diffuse midline glioma H3 K27 M mutant, GBM G34 – glioblastoma IDH wildtype subclass H3 G34 mutant, GBM MYCN – glioblastoma IDH wildtype subclass MYCN, GBM MES – glioblastoma IDH wildtype subclass MES, GBM RTK I/II/III – glioblastoma IDH wildtype subclass(es) RTK I/II/III, GBM MID – glioblastoma IDH wildtype subclass midline, AAP – anaplastic astrocytoma with piloid features, A IDH – IDH mutant glioma, PA PF – low grade glioma subclass posterior fossa pilocytic astrocytoma. ** Frequencies of these tumors may be biased depending on the supplier diagnosis, the date of diagnosis and the availability and application of antibodies or sequencing methods detecting IDH and histone mutations