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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

Fig. 5

Sarm1 deletion attenuates the pre-weaning loss of male TDP-43Q331K mice but does not influence age-related behavioural impairments. a. Ratios of mice genotyped at birth (all of which were successfully weaned) broken down by gender. Female (χ2 = 0.289, d.f. = 3, P = 0.962), Male (χ2 = 8.387, d.f. = 3, P = 0.039); Chi square test. b. Latency to fall of male transgenic mice on accelerating rotarod (n = 5–10 NTG; n = 4–8 Q331K-Sarm1+/−; n = 6–13 Q331K-Sarm1−/− mice per genotype). Fixed effects (Age x Genotype) P < 0.0001. Pairwise comparisons: Q331K-Sarm1+/− vs. Q331K-Sarm1−/−: ns P = 0.6873. c. Weights of male mice (n = 4–10 NTG; n = 4–8 Q331K-Sarm1+/−; n = 13 Q331K-Sarm1−/− mice per genotype). Fixed effects (Age x Genotype) P = 0.0113. Pairwise comparisons: Q331K-Sarm1+/− vs. Q331K-Sarm1−/−: ns P = 0.8984. d. Score of male mice on hindlimb clasping test (n = 5–10 NTG; n = 4–8 Q331K-Sarm1+/−; n = 3–13 Q331K-Sarm1−/− mice per genotype). Fixed effects (Age x Genotype) P = 0.0003. Pairwise comparisons: Q331K-Sarm1+/− vs. Q331K-Sarm1−/−: ns P = 0.0764. For (b-d) Mixed-effects analysis followed by Holm-Sidak post-hoc test for pairwise comparisons. e. Number of marbles buried at different ages (n = 7–12 NTG; n = 4–9 Q331K-Sarm1+/−; n = 7–18 Q331K-Sarm1−/− mice per genotype). ANOVA Genotype P < 0.0001. Pairwise comparisons: 3–4 months, Q331K-Sarm1+/− vs. Q331K-Sarm1−/−: ns P = 0.4154; 5–7 months, Q331K-Sarm1+/− vs. Q331K-Sarm1−/−: ns P > 0.9999. Two-way ANOVA followed by Holm-Sidak post-hoc test for pairwise comparisons. For (b-e) ****P < 0.0001; error bars represent mean ± s.e.m

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