Table 5 Enrichment Analysis (C9Plus vs. C9Minus)
Module | Dir | Source | Order | Process/Pathway | P-value | FDR |
|---|---|---|---|---|---|---|
MEblack | Up | KEGG | 1 | KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION | 3.31E-06 | 4.34E-04 |
2 | KEGG_SPLICEOSOME | 3.80E-04 | 0.02 | |||
GO-BP | 1 | GO_PROTEIN_FOLDING | 4.24E-29 | 8.97E-26 | ||
2 | GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN | 6.40E-19 | 7.55E-16 | |||
MEdarkorange | Up | KEGG | 1 | KEGG_ECM_RECEPTOR_INTERACTION | 0.04 | 0.67 |
2 | KEGG_FOCAL_ADHESION | 0.10 | 1.00 | |||
GO-BP | 1 | GO_PROTEIN_HETEROOLIGOMERIZATION | 0.001 | 0.06 | ||
2 | GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS | 0.003 | 0.14 | |||
MEblue | Up | KEGG | 1 | KEGG_SPLICEOSOME | 0.002 | 0.09 |
2 | KEGG_RNA_DEGRADATION | 0.04 | 0.68 | |||
GO-BP | 1 | GO_RNA_SPLICING | 7.85E-12 | 4.57E-09 | ||
2 | GO_RNA_PROCESSING | 9.98E-12 | 5.56E-09 | |||
MEyellow | Down | KEGG | 1 | KEGG_PEROXISOME | 4.48E-06 | 5.00E-04 |
2 | KEGG_DNA_REPLICATION | 3.65E-04 | 0.02 | |||
GO-BP | 1 | GO_SMALL_MOLECULE_METABOLIC_PROCESS | 4.33E-09 | 1.58E-06 | ||
2 | GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS | 3.34E-08 | 1.01E-05 | |||
MEred | Down | KEGG | 1 | KEGG_ECM_RECEPTOR_INTERACTION | 1.52E-07 | 3.38E-05 |
2 | KEGG_FOCAL_ADHESION | 3.67E-06 | 4.34E-04 | |||
GO-BP | 1 | GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION | 1.56E-16 | 1.45E-13 | ||
2 | GO_TISSUE_DEVELOPMENT | 2.61E-12 | 1.54E-09 | |||
MEwhite | Down | KEGG | 1 | KEGG_RIBOSOME | 1.49E-05 | 0.001 |
2 | KEGG_PROTEIN_EXPORT | 0.01 | 0.32 | |||
GO-BP | 1 | GO_PEPTIDE_METABOLIC_PROCESS | 1.57E-07 | 4.08E-05 | ||
2 | GO_CELLULAR_AMIDE_METABOLIC_PROCESS | 6.22E-07 | 1.34E-04 | |||
MEgreen | Down | KEGG | 1 | KEGG_PARKINSONS_DISEASE | 1.74E-08 | 5.23E-06 |
2 | KEGG_HUNTINGTONS_DISEASE | 1.50E-06 | 2.17E-04 | |||
GO-BP | 1 | GO_GOLGI_VESICLE_TRANSPORT | 3.53E-09 | 1.33E-06 | ||
2 | GO_SMALL_MOLECULE_METABOLIC_PROCESS | 5.83E-09 | 2.05E-06 | |||
MEroyalblue | Down | KEGG | 1 | KEGG_FOCAL_ADHESION | 1.56E-07 | 3.38E-05 |
2 | KEGG_COMPLEMENT_AND_COAGULATION_CASCADES | 2.70E-07 | 5.03E-05 | |||
GO-BP | 1 | GO_VASCULATURE_DEVELOPMENT | 2.11E-17 | 2.18E-14 | ||
2 | GO_BLOOD_VESSEL_MORPHOGENESIS | 4.64E-17 | 4.65E-14 | |||
MEsalmon | Up | KEGG | 1 | KEGG_PROTEASOME | 3.80E-06 | 4.36E-04 |
2 | KEGG_ALZHEIMERS_DISEASE | 2.59E-04 | 0.02 | |||
GO-BP | 1 | GO_MITOCHONDRION_ORGANIZATION | 1.02E-11 | 5.64E-09 | ||
2 | GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY | 2.34E-08 | 7.38E-06 | |||
MEgreenyellow | Up | KEGG | 1 | KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM | 1.26E-04 | 0.009 |
2 | KEGG_BETA_ALANINE_METABOLISM | 9.26E-04 | 0.04 | |||
GO-BP | 1 | GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION | 3.80E-09 | 1.41E-06 | ||
2 | GO_GABAERGIC_NEURON_DIFFERENTIATION | 8.92E-09 | 3.02E-06 | |||
MEturquoise | Up | KEGG | 1 | KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | 6.26E-13 | 2.72E-10 |
2 | KEGG_CALCIUM_SIGNALING_PATHWAY | 3.22E-09 | 1.14E-06 | |||
GO-BP | 1 | GO_SYNAPTIC_SIGNALING | 2.36E-50 | 6.29E-47 | ||
2 | GO_MODULATION_OF_SYNAPTIC_TRANSMISSION | 6.15E-40 | 1.47E-36 |