Fig. 4

a One specific group of genes is visualized in a heat map: the green module. b A heat map is displayed for the yellow module. High expression levels are shown in red and low levels in blue. Below every heat map, the first principal component of a given module (module eigengene) is displayed for each sample. Most C9orf72 expansion carriers (C9Plus) appear to have relatively low levels as compared to patients without this expansion (C9Minus) or to control subjects (Control)