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Table 2 Among higher abundance proteins that were mildly enriched in FXTAS samples were other protein turnover agents and proteins involved in non-homologous end joining (NHEJ)

From: Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome

Proteins Averaged FXTAS over Control
p62/SQSTM1 237.5 (0.19/0.0008)
Small ubiquitin-related modifier 2 (SUMO2) 11.4 (9.88/0.87)
Small ubiquitin-related modifier 3 (SUMO3) 12.9 (0.09/0.007)
Small ubiquitin-related modifier 1 (SUMO1) 7.2 (0.43/0.06)
Ubiquitin (RS27A) 3.9 (0.51/0.13)
Carbonyl reductase [NADPH] 1 (CBR1) 20.5 (0.41/0.02)
14-3-3 protein theta (1433T) 15.0 (0.12/0.008)
Gelsolin (GSN) 11.0 (0.11/0.01)
Peptidyl-prolyl cis-trans isomerase A (PPIA) 5.4 (0.54/0.10)
Triosephosphate isomerase (TPIS) 3.5 (0.07/0.02)
X-ray repair cross-complementing protein 5 (XRCC5) 3.3 (0.20/0.06)
Creatine kinase B-type (KCRB) 3.2 (0.51/0.16)
Poly [ADP-ribose] polymerase 1 (PARP1) 2.7 (0.38/0.14)
Splicing factor U2AF 35 kDa subunit-like protein (U2AF5) 2.6 (0.13/0.05)
Isocitrate dehydrogenase [NADP] (IDHP) 2.3 (0.09/0.04)
X-ray repair cross-complementing protein 6 (XRCC6) 2.0 (0.34/0.17)
Centromere protein V (CENPV) 1.7 (0.38/0.22)
ATP-dependent RNA helicase (DDX1) 1.4 (0.10/0.07)
Profilin-1 (PROF1) 1.3 (0.08/0.06)
Alpha-crystallin B chain (CRYAB) 1.3 (2.11/1.63)
  1. Excluding SUMO 2, proteins that showed at least 3-fold enrichment in both FXTAS samples over age matched control samples are bolded
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