Fig. 3
From: Telomere alterations in neurofibromatosis type 1-associated solid tumors
Telomere alterations are associated with overall survival in NF1-associated glioma and MPNST. Kaplan-Meier curves and log rank tests demonstrate worse overall survival in patients with ALT-positive NF1-gliomas compared to patients with ALT-negative NF1-gliomas (p < 0.0001) (a). Additionally, overall survival was intermediate for patients with tumors with long telomeres (but lacking ALT), and longer for patients with tumors with normal telomeres (p = 0.0021) (b). In the MPNST cohort known to be NF1-associated, the survival difference between ALT-positive and ALT-negative tumors was not statistically significant (p = 0.11) (c). However, overall survival was inferior for tumors with ALT, intermediate for tumors with normal telomeres, and superior for tumors with short telomeres (p = 0.0052), when further subdivided (d)