Fig. 2
From: Telomere alterations in neurofibromatosis type 1-associated solid tumors
ALT-positive MPNST represent a distinct molecular subgroup. ALT-positive NF1-MPNST (case 114) (a), with ALT (b), ATRX protein loss (c), but preserved H3K27 trimethylation (d). Next generation sequencing demonstrated concurrent ATRXp.E511Kfs*3 and a NF1 splice site mutation (c.7259-1G > A) (e), but no EED or SUZ12 mutations