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Table 2 Semi-quantitative grading of pSer129 αsyn pathology

From: Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

pSer129 pathology
  SNpc Amyg. Cing.
LBD
 Case 1 ++ +++ +++
 Case 2 +++ +++ +++
 Case 3 ++ +++ +++
 Case 4 +++ ++ +
 Case 5 ++ ++ ++
 Case 6 ++ + ++
 Case 7 +++ +++ +++
 Case 8 +++ +++ +++
 Case 9 ++ ++ ++
AD/ALB
 Case 15 −/+
 Case 16 +
 Case 17 −/+ ++
 Case 18 +++
 Case 19 ++
 Case 20 ++
 Case 21 ++
 Case 22 +
 Case 23 +++
  1. Following immunohistochemical staining with antibody EP1536Y and no formic acid retrieval, semi-quantitative grading was assigned to each LBD and AD/ALB case for 3 separate regions (SNpc substantia nigra pars compacta, cing. cingulate cortex, amyg. amygdala). The presence of pSer129 positive inclusions was semi-quantitatively graded at 10x magnification on a multi-tiered scale, with “-” representing non-reactivity, “−/+” very rare, “+” mild, “++” moderate, and “+++” representing the strongest level of reactivity