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Table 1 Autopsy case demographics

From: Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

  Age at Onset Age at Death Pathology Diagnosis APOE Braak Stage Thal Phase CERAD Score IHC Biochem
LBD
 Case 1 71 81 LBD/AD/CAA ε3/ε3 V-VI 5 C3 A, C, M
 Case 2 60 68 LBD/AD/CAA ε3/ε4 VI 5 C3 A, C, M C
 Case 3 70 83 LBD/AD ε3/ε4 VI 5 C3 A, C, M
 Case 4 70 80 LBD/AD ε3/ε3 III 3 C2 A, C, M
 Case 5 73 80 LBD/AD ε3/ε4 VI 5 C3 A, C, M MTL
 Case 6 51 62 LBD/AD ε3/ε3 II 5 C3 A, C, M
 Case 7 63 67 LBD/AD ε3/ε4 III 4 C3 A, C, M A, MTL
 Case 8 62 67 LBD/AD ε3/ε4 III 3 C1 A, C, M
 Case 9 84 90 LBD/AD ε3/ε3 III 5 C2 A, C, M
 Case 10 67 72 LBD/AD ε2/ε3 V-VI 3 C2 C
 Case 11 59 66 LBD/AD/CAA ε3/ε4 IV 2 C3 C
 Case 12 40 78 LBD/AD/CAA ε3/ε3 IV 3 C3 MTL
 Case 13 64 74 LBD/AD/CAA ε2/ε4 VI 5 C2 MTL
 Case 14 62 68 LBD/AD ε4/ε4 V 3 C3 MTL
AD/ALB
 Case 15 (> 90) (> 90) AD/CAA ε2/ε3 V-VI 3 C3 A, C, M
 Case 16 82 AD ε2/ε3 III 3 C1 A, C, M
 Case 17 58 63 AD ε3/ε3 VI 3 C3 A, C, M
 Case 18 75 83 AD/CAA ε3/ε4 V 3 C2 A, C, M
 Case 19 62 77 AD/PSP II 3 C2 A, C, M
 Case 20 57 64 AD/CAA ε3/ε3 V 5 C3 A, C, M MTL
 Case 21 40 77 AD/CAA ε2/ε3 II 2 C2 A, C, M MTL
 Case 22 (> 90) (> 90) AD/CAA ε3/ε3 VI 4 C3 A, C, M
 Case 23 53 67 AD ε3/ε3 VI 3 C3 A, C, M
Controls
 Case 24 87 No neurological diagnosis ε2/ε3 0 0 0 MTL
 Case 25 56 67 FTLD-TDP ε3/ε3 0 0 0 MTL
 Case 26 82 Cerebrovascular arteriolosclerosis ε2/ε3 II 2 C1 C
 Case 27 52 No neurological diagnosis ε3/ε4 II 2 C1 C
  1. LBD Lewy body dementia, AD Alzheimer’s disease, AD/ALB Alzheimer’s disease with Amygdala restricted Lewy bodies, CAA cerebral amyloid angiopathy, PSP progressive supranuclear palsy, FTLD-TDP frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions, APOE apolipoprotein E, A amygdala, C cingulate cortex, M midbrain, MTL medial temporal lobe