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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

Fig. 8

αsyn aggregates within the LBD amygdala often co-localizes with Alzheimer’s disease-type inclusion pathology. a Amygdala sections from 4 different LBD cases (2, 4, 7 and 9) stained with central αsyn antibody 3H11 along with FA retrieval reveal abundant αsyn dystrophic neurites within Aβ senile plaques. These αsyn-positive dystrophic neurites within Aβ plaques were common within the LBD amygdalas but rare in the AD/ALB amygdalas examined. Cases are indicated in lower right corner. Scale bar 50 μm. b Double labeled immunofluorescence microscopy of LBD amygdala sections from 2 different LBD cases using rabbit monoclonal anti-pSer129 αsyn antibody EP1536Y and mouse monoclonal anti-pThr205 tau antibody 7F2 or mouse monoclonal anti-Aβ antibody 33.1.1. Co-localization of tau and αsyn aggregates was common in the LBD amygdala both in neuronal cell bodies and processes. Scale bar 50 μm

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