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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

Fig. 7

αsyn astrocytic pathology is common in LBD amygdala. a Amygdala sections from 4 different LBD cases (1, 2, 7 and 8) were labeled with central αsyn antibodies either 3H11 or 5G4 along with FA retrieval. Typically, more than 5 cells with astrocytic morphology (depicted with arrowheads) stained with these antibodies was readily observed per field; insets show examples for each case and each antibody. Although astrocytic αsyn inclusions may be present in other brain regions, they are only this densely abundant within the MTL, particularly the amygdala. Cases are indicated in lower right corner. Scale bar 50 μm. b Double labeling immunofluorescent analysis of LBD amygdala sections using central αsyn antibody 3H11 in conjunction with astrocytic markers GFAP or vimentin. Astrocytic αsyn often appears as vesicular granules outlining 2–3 astrocytic processes as opposed to the more uniform αsyn staining seen within nearby cortical LBs, suggesting a differing subcellular co-localization or form of aggregates. Scale bar 30 μm

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