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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

Fig. 4

Quantitation of LRP in LBD brain regions across a panel of antibodies. a Three areas of dense pathology within the cingulate (C) or amygdala (A) of LBD (N = 9) cases stained with 3 different antibodies without or with (FA) retrieval were subject to positive pixel analysis; average positivity and error bars (std) are displayed for each region and antibody without or with FA. All cases were averaged for each region and antibody for comparison. Without FA retrieval, all antibodies detect similar amounts of LRP within the amygdala versus the cingulate cortex; with FA retrieval a large increase in labeled amygdala pathology is evident with all antibodies whereas a lesser increase in pathology is seen in the cingulate cortex and only with antibody 94-3A10. With FA retrieval, the average amygdala pathology burden is significantly greater than the cingulate cortex for all antibodies. b A statistical summary of positivity comparisons for data presented in A. The average positivity for each antibody between and within regions along with presence or absence of FA retrieval were tested for significant differences using one-way ANOVA and the Sidak post-hoc multiple comparisons test. Mean difference is the absolute difference in positivity values

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