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Table 2 Comparison of sensitivity and specificity of MOG Ab detection assays

From: Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination

  Total cohort Limited cohort
Sensitivity % (CI) Specificity % (CI) Sensitivity % (CI) Specificity % (CI)
Children N = 171   N = 80  
 Live flow assay IgG (H + L)a 89.7 (83–94) 97.1 (83.4–99.9) 87.9 (77–94.3) 100 (73.2–100)
 Live flow assay (IgG1)b 89.8 (82.8–94.2) 94.3 (79.5–99) 88.3 (76.8–94.8) 100 (73.2–100)
 Fixed flow assaya 50.7 (42.1–59.4) 100 (87.7–100) 43.9 (31.9–56.7) 100 (73.2–100)
 Fixed biochip assaya 60.6 (47.8–72.2) 100 (73.2–100)
Adults N = 172   N = 70  
 Live flow assay IgG (H + L)a 93.9 (88–97.2) 97.5 (85.3–99.9) 92.3 (80.6–97.5) 100 (78.1–100)
 Live flow assay (IgG1)b 87.7 (80.5–92.6) 97.5 (85.3–99.9) 81.5 (68.1–90.3) 95.5 (75.1–99.8)
 Fixed flow assaya 52.3 (43.4–61) 100 (89.1–100) 50 (36–64) 100 (78.1–100)
 Fixed biochip assaya 55.8 (41.4–69.3) 100 (56.1–100)
  1. aAnalysis included 134 children and 132 adults (total cohort), and 66 children and 52 adults (limited cohort) with reported MOG Ab-associated disorders, and 37 children and 40 adults (total cohort), and 14 children and 18 adults (limited cohort) with not yet reported MOG Ab-associated disorders and disorders not associated with MOG Ab
  2. bAnalysis included 127 children and 130 adults (total cohort), and 60 children and 54 adults (limited cohort) with reported MOG Ab-associated disorders, and 35 children and 40 adults (total cohort), and 14 children and 22 adults (limited cohort) with not yet reported MOG Ab-associated disorders and disorders not associated with MOG Ab. CI = 95% confidence interval. Groups are described in Materials and methods
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