Table 2 Comparison of sensitivity and specificity of MOG Ab detection assays

Children

N = 171

N = 80

 Live flow assay IgG (H + L)^a

89.7 (83–94)

97.1 (83.4–99.9)

87.9 (77–94.3)

 Live flow assay (IgG1)^b

89.8 (82.8–94.2)

94.3 (79.5–99)

88.3 (76.8–94.8)

 Fixed flow assay^a

50.7 (42.1–59.4)

100 (87.7–100)

43.9 (31.9–56.7)

 Fixed biochip assay^a

–

–

60.6 (47.8–72.2)

Adults

N = 172

N = 70

 Live flow assay IgG (H + L)^a

93.9 (88–97.2)

97.5 (85.3–99.9)

92.3 (80.6–97.5)

 Live flow assay (IgG1)^b

87.7 (80.5–92.6)

97.5 (85.3–99.9)

81.5 (68.1–90.3)

 Fixed flow assay^a

52.3 (43.4–61)

100 (89.1–100)

50 (36–64)

 Fixed biochip assay^a

–

–

55.8 (41.4–69.3)