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Table 1 Clinical characteristics of native-MOG Ab+ demyelination patients

From: Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination

  Children Adults All patients
N (% total) Female
F:M (ratio)
Age
Median (IQR) a
N (% total) Female
F:M (ratio)
Age
Median (IQR) a
N (% total) Female
F:M (ratio)
Age
Median (IQR) a
All phenotypes (All)b 139 (All) 73:63 (1.2) 8 (5–12) 148 (All) 92:56 (1.6) 40 (30–54) 287 (All) 165:119 (1.4) 22 (8–43)
 Monophasic course 79 (57) 39:40 (1) 7 (4–11) 57 (39) 37:20 (1.9) 43 (30–56) 136 (47) 76:60 (1.3) 14 (6–38)
 Relapsing course 44 (32) 29:15 (1.9) 8 (6–13) 61 (41) 37:24 (1.5) 40 (33–51) 105 (37) 66:39 (1.7) 30 (10–44)
 Unknown 16 (12) 5:8 (0.6) 9 (4–13) 30 (20) 18:12 (1.5) 39 (27–53) 46 (16) 23:20 (1.2) 25 (12–49)
ON 38 (27 of All) 26:12 (2.2) 10 (7–13) 91 (61 of All) 58:33 (1.8) 44 (33–55) 129 (45 of All) 84:45 (1.9) 34 (15–49)
 Monophasic ON 22 (58) 14:8 (1.8) 9 (7–13) 43 (47) 29:14 (2.1) 46 (33–57) 65 (50) 43:22 (2.0) 32 (12–54)
 Relapsing ON 16 (43) 12:4 (3.0) 11 (8–16) 48 (53) 29:19 (1.5) 40 (33–51) 64 (50) 41:23 (1.8) 34 (17–49)
  BON 18 (47 of ON) 11:7 (1.6) 9 (6–14) 40 (44 of ON) 25:15 (1.7) 39 (33–55) 58 (45 of ON) 36:22 (1.6) 33 (13–49)
   Monophasic BON 14 (78) 8:6 (1.3) 9 (5–13) 23 (58) 15:8 (1.9) 47 (31–57) 37 (64) 23:14 (1.6) 29 (10–49)
   Relapsing BON 4 (22) 3:1 (3.0) 12 (6–17) 17 (43) 10:7 (1.4) 36 (33–51) 21(36) 13:8 (1.6) 34 (21–49)
  UON 17 (45 of ON) 13:4 (3.3) 10 (9–13) 45 (49 of ON) 29:16 (1.8) 44 (32–54) 62 (48 of ON) 42:20 (2.1) 34 (17–50)
   Monophasic UON 8 (47) 6:2 (3.0) 10 (8–13) 20 (44) 14:6 (2.3) 45 (32–59) 28 (45) 20:8 (2.5) 34 (14–54)
   Relapsing UON 9 (53) 7:2 (3.5) 11 (8–15) 25 (56) 15:10 (1.5) 40 (32–53) 34 (55) 22:12 (1.8) 34 (17–50)
  Relapsing ON mixed 3 (8 of ON) 2:1 (2.0) 10 (9–15) 6 (7 of ON) 4:2 (2.0) 49 (36–58) 9 (7 of ON) 6:3 (2.0) 39 (12–52)
ADEM 53 (38 of All) 5 (3–8) 5 (3–8) 1 (1 of All) 1:0 (−) 25 (−) 54 (19 of All) 28:26 (1.1) 5 (3–8)
 Monophasic ADEM 42 (79) 20:22 (0.9) 4 (3–8) 42 (78) 20:22 (0.9) 4 (3–8)
 Relapsing ADEMc 11 (21) 7:4 (1.8) 6 (5–8) 1 (100) 1:0 (−) 25 (−) 12 (22) 8:4 (2.0) 6 (5–9)
ON/TM 9 (6 of All) 5:4 (1.3) 54 (28–59) 9 (3 of All) 5:4 (1.3) 54 (28–59)
 Monophasic ON/TM 3 (33) 2:1 (2.0) 54 (43–60) 3 (33) 2:1 (2.0) 54 (43–60)
 Relapsing ON/TM 6 (67) 3:3 (1.0) 44 (25–58) 6 (67) 3:3 (1.0) 44 (25–58)
LETM 10 (7 of All) 3:7 (0.4) 11 (6–15) 8 (5 of All) 5:3 (1.7) 28 (24–33) 18 (6 of All) 8:10 (0.8) 18 (10–29)
 Monophasic LETM 10 (100) 3:7 (0.4) 11 (6–15) 7 (88) 4:3 (1.3) 26 (23–31) 17 (94) 7:10 (0.9) 17 (9–26)
 Relapsing LETM 1 (13) 1:0 (−) 34 (−) 1 (6) 1:0 (−) 34 (−)
Relapsing ADEM/ON 10 (7 of All) 4:5 (0.8) 6 (5–10) 10 (3 of All) 4:5 (0.8) 6 (5–10)
Monophasic CIS 1 (1 of All) 1:0 (−) 5 (−) 1 (1 of All) 1:0 (−) 5 (−)
Otherd 5 (3 of All) 2:3 (0.7) 10 (6–15) 7 (5 of All) 3:4 (0.8) 32 (27–42) 12 (4 of All) 5:7 (0.6) 28 (15–40)
Phenotypes n < 3e 6 (4 of All) 5:2 (2.5) 8 (6–11) 9 (6 of All) 5:4 (1.3) 40 (33–44) 15 (5 of All) 10:6 (1.7) 25 (8–42)
Unknown Phenotype 16 (11 of All) 5:8 (0.6) 9 (4–13) 23 (16 of All) 15:8 (1.9) 43 (26–54) 39 (14 of All) 20:16 (1.3) 25 (12–49)
  1. ADEM Acute disseminated encephalomyelitis, BON Bilateral optic neuritis, CIS Clinically isolated syndrome, LETM Longitudinally extensive transverse myelitis, ON mixed Combination of BON and UON, ON/TM Simultaneous ON and TM, UON Unilateral optic neuritis
  2. aIQR Interquartile range
  3. bPhenotype of baseline sample
  4. cRelapsing ADEM is multiphasic ADEM according to [30]
  5. dOther: uncommon and atypical MOG Ab-associated phenotypes, including monophasic CIS/LETM, seizures, cerebellar, brainstem, brainstem and headache and fatigue, acute psychosis, optic perineuritis
  6. ePhenotypes with less than three patients; children, monophasic LETM/UON (1), monophasic short TM (1), relapsing BON/LETM (2), relapsing BON/LETM/ADEM (1), relapsing LETM/UON (1); adults, monophasic short TM (2), monophasic LETM/ADEM (1), monophasic LETM/brainstem (1), relapsing short TM (2), relapsing TM mixed (1), relapsing BON/LETM/ADEM (1), relapsing ON/brainstem/short TM (1)
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