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Table 1 Clinical characteristics of native-MOG Ab+ demyelination patients

From: Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination

 

Children

Adults

All patients

N (% total)

Female

F:M (ratio)

Age

Median (IQR) a

N (% total)

Female

F:M (ratio)

Age

Median (IQR) a

N (% total)

Female

F:M (ratio)

Age

Median (IQR) a

All phenotypes (All)b

139 (All)

73:63 (1.2)

8 (5–12)

148 (All)

92:56 (1.6)

40 (30–54)

287 (All)

165:119 (1.4)

22 (8–43)

 Monophasic course

79 (57)

39:40 (1)

7 (4–11)

57 (39)

37:20 (1.9)

43 (30–56)

136 (47)

76:60 (1.3)

14 (6–38)

 Relapsing course

44 (32)

29:15 (1.9)

8 (6–13)

61 (41)

37:24 (1.5)

40 (33–51)

105 (37)

66:39 (1.7)

30 (10–44)

 Unknown

16 (12)

5:8 (0.6)

9 (4–13)

30 (20)

18:12 (1.5)

39 (27–53)

46 (16)

23:20 (1.2)

25 (12–49)

ON

38 (27 of All)

26:12 (2.2)

10 (7–13)

91 (61 of All)

58:33 (1.8)

44 (33–55)

129 (45 of All)

84:45 (1.9)

34 (15–49)

 Monophasic ON

22 (58)

14:8 (1.8)

9 (7–13)

43 (47)

29:14 (2.1)

46 (33–57)

65 (50)

43:22 (2.0)

32 (12–54)

 Relapsing ON

16 (43)

12:4 (3.0)

11 (8–16)

48 (53)

29:19 (1.5)

40 (33–51)

64 (50)

41:23 (1.8)

34 (17–49)

  BON

18 (47 of ON)

11:7 (1.6)

9 (6–14)

40 (44 of ON)

25:15 (1.7)

39 (33–55)

58 (45 of ON)

36:22 (1.6)

33 (13–49)

   Monophasic BON

14 (78)

8:6 (1.3)

9 (5–13)

23 (58)

15:8 (1.9)

47 (31–57)

37 (64)

23:14 (1.6)

29 (10–49)

   Relapsing BON

4 (22)

3:1 (3.0)

12 (6–17)

17 (43)

10:7 (1.4)

36 (33–51)

21(36)

13:8 (1.6)

34 (21–49)

  UON

17 (45 of ON)

13:4 (3.3)

10 (9–13)

45 (49 of ON)

29:16 (1.8)

44 (32–54)

62 (48 of ON)

42:20 (2.1)

34 (17–50)

   Monophasic UON

8 (47)

6:2 (3.0)

10 (8–13)

20 (44)

14:6 (2.3)

45 (32–59)

28 (45)

20:8 (2.5)

34 (14–54)

   Relapsing UON

9 (53)

7:2 (3.5)

11 (8–15)

25 (56)

15:10 (1.5)

40 (32–53)

34 (55)

22:12 (1.8)

34 (17–50)

  Relapsing ON mixed

3 (8 of ON)

2:1 (2.0)

10 (9–15)

6 (7 of ON)

4:2 (2.0)

49 (36–58)

9 (7 of ON)

6:3 (2.0)

39 (12–52)

ADEM

53 (38 of All)

5 (3–8)

5 (3–8)

1 (1 of All)

1:0 (−)

25 (−)

54 (19 of All)

28:26 (1.1)

5 (3–8)

 Monophasic ADEM

42 (79)

20:22 (0.9)

4 (3–8)

–

–

–

42 (78)

20:22 (0.9)

4 (3–8)

 Relapsing ADEMc

11 (21)

7:4 (1.8)

6 (5–8)

1 (100)

1:0 (−)

25 (−)

12 (22)

8:4 (2.0)

6 (5–9)

ON/TM

–

–

–

9 (6 of All)

5:4 (1.3)

54 (28–59)

9 (3 of All)

5:4 (1.3)

54 (28–59)

 Monophasic ON/TM

–

–

–

3 (33)

2:1 (2.0)

54 (43–60)

3 (33)

2:1 (2.0)

54 (43–60)

 Relapsing ON/TM

–

–

–

6 (67)

3:3 (1.0)

44 (25–58)

6 (67)

3:3 (1.0)

44 (25–58)

LETM

10 (7 of All)

3:7 (0.4)

11 (6–15)

8 (5 of All)

5:3 (1.7)

28 (24–33)

18 (6 of All)

8:10 (0.8)

18 (10–29)

 Monophasic LETM

10 (100)

3:7 (0.4)

11 (6–15)

7 (88)

4:3 (1.3)

26 (23–31)

17 (94)

7:10 (0.9)

17 (9–26)

 Relapsing LETM

–

–

–

1 (13)

1:0 (−)

34 (−)

1 (6)

1:0 (−)

34 (−)

Relapsing ADEM/ON

10 (7 of All)

4:5 (0.8)

6 (5–10)

–

–

–

10 (3 of All)

4:5 (0.8)

6 (5–10)

Monophasic CIS

1 (1 of All)

1:0 (−)

5 (−)

–

–

–

1 (1 of All)

1:0 (−)

5 (−)

Otherd

5 (3 of All)

2:3 (0.7)

10 (6–15)

7 (5 of All)

3:4 (0.8)

32 (27–42)

12 (4 of All)

5:7 (0.6)

28 (15–40)

Phenotypes n < 3e

6 (4 of All)

5:2 (2.5)

8 (6–11)

9 (6 of All)

5:4 (1.3)

40 (33–44)

15 (5 of All)

10:6 (1.7)

25 (8–42)

Unknown Phenotype

16 (11 of All)

5:8 (0.6)

9 (4–13)

23 (16 of All)

15:8 (1.9)

43 (26–54)

39 (14 of All)

20:16 (1.3)

25 (12–49)

  1. ADEM Acute disseminated encephalomyelitis, BON Bilateral optic neuritis, CIS Clinically isolated syndrome, LETM Longitudinally extensive transverse myelitis, ON mixed Combination of BON and UON, ON/TM Simultaneous ON and TM, UON Unilateral optic neuritis
  2. aIQR Interquartile range
  3. bPhenotype of baseline sample
  4. cRelapsing ADEM is multiphasic ADEM according to [30]
  5. dOther: uncommon and atypical MOG Ab-associated phenotypes, including monophasic CIS/LETM, seizures, cerebellar, brainstem, brainstem and headache and fatigue, acute psychosis, optic perineuritis
  6. ePhenotypes with less than three patients; children, monophasic LETM/UON (1), monophasic short TM (1), relapsing BON/LETM (2), relapsing BON/LETM/ADEM (1), relapsing LETM/UON (1); adults, monophasic short TM (2), monophasic LETM/ADEM (1), monophasic LETM/brainstem (1), relapsing short TM (2), relapsing TM mixed (1), relapsing BON/LETM/ADEM (1), relapsing ON/brainstem/short TM (1)