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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination

Fig. 6

Major MOG Ab binding Patterns in children and adults with demyelinating disorders. a Native-MOG Ab binding was divided into eight patterns characterized by Proline42 epitope (orange), conformational sensitivity (red), and affinity (purple). MOG Ab responses from paediatric (42%) and adult (34%) sera targeted P42 and included conformation insensitive low affinity Ab (Pattern 1), followed by 30% of children and 28% of adults with similar low affinity response against Proline42, but were conformation-sensitive (Pattern 3). Responses targeting an epitope outside of Proline42 (light-orange) were of low affinity but were more sensitive to conformational changes to MOG (lighter red). Color intensity decreases with lower frequency of patients in each category (5 children and 3 adults not tested for affinity). b Association between clinical course and MOG Ab binding Patterns. Adults with a monophasic disease course were likely to present Pattern 1 (P = 0.028). Patterns 5 and 7 were more likely to include adults with a relapsing course (P = 0.035). Scale bar denotes frequency of patients in each binding Pattern. Affinity was not assessed in 2 monophasic (1 child, 1 adult), 5 relapsing patients (4 children, 1 adult), and one adult with unknown phenotype. Ab = antibody

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