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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination

Fig. 5

A small population of children and adults harbor high affinity MOG Ab. a 20/134 children (15%) and 26/145 adult sera (18%) bound to native-MOG1–117 and had high affinity MOG Ab, whereas no controls (grey), and one native-MOG Ab- child and one adult were positive for native-MOG1–117 Ab (grey). Dotted line represents the positivity threshold and native-MOG1–117 Ab positivity is shown between brackets. b Presence of high affinity native-MOG1–117 Ab (purple) were not associated with native-MOG Ab titers, with similar detection of high affinity MOG Ab (purple) in children and adults across low, mid, and high native-MOG Ab titers. c High affinity MOG Ab was sustained for up to 1.6 years in 5/6 children (median disease duration 3.4 months, IQR 1.6–5.8) and 4.9 years in all five adults (median disease duration 5.1 months, IQR 4.2–13.7), whereas high affinity MOG Ab disappeared in one child at 20.8 months. Ab- = antibody negative, Ab+ = antibody positive, CTL = controls, native-MOG1–117 Ab = high affinity MOG Ab binding to extracellular MOG, native-MOG = native human MOG, OD = optical density

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