Fig. 4From: Downregulation of Nodal inhibits metastatic progression in retinoblastomaReduction of Nodal inhibits invasion of Y79 cells in zebrafish. a Representative images of the localization of Y79-GFP cells (highlighted in green) expressing Nodal shRNA (sequence A) or scrambled shRNA at 1 and 4 dpi after intravitreal injection in zebrafish. b We observed 34% reduction in the fold-change of the minimum bounding sphere (MBS, highlighted in red, 50āĪ¼m grid for scale) diameter (Ī¼m) between day 1 and day 4 post-injection images when zebrafish larvae (nā=ā24) were injected intravitreally with Y79-GFP cells expressing Nodal shRNA, compared to scrambled shRNA (nā=ā23). Effect size: -0.44; 95% CI: āā0.67, āā0.22; pā=ā2.96āĆā10āā4; 50āĪ¼m grid for scaleBack to article page