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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

Fig. 7

Neighborhood and spatial variance component analyses for the early and late lesions. (a, b) Neighborhood analysis heatmaps of all significant pairwise phenotype interactions (red) and avoidances (blue) in the (a) early and (b) late lesions. White represents no significant spatial relationship. Dark boxes are highly significant spatial relationships (p < 0.01). Lightly shaded boxes are less significant relationships (p < 0.05) and interactions between cells of the same or spatially adjacent phenotypes. Rows visualize the significance of a phenotype surrounded by other phenotypes, and columns visualize the significance of a phenotype surrounding other phenotypes. (c, d) Spatial variance component analysis (SVCA) for the (c) early and (d) late lesions, showing the proportion of marker expression variance attributable to neighboring cell influences, environmental stimuli, cell-intrinsic factors and residual noise in different lesion zones. Additional plots show the average proportion of marker variance attributable to each factor in different lesion zones. G/WM = gray and white matter; WM = white matter; PVS = perivascular space; NAWM = normal-appearing white matter

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