Fig. 1

Kaplan-Meier survival curves demonstrating survival differences using 10% overall CNV as a threshold for poor clinical outcome (p = 0.0020) (a), using 15% overall CNV as a threshold for poor clinical outcome (p < 0.0001) (b), and using 18% overall as a threshold for poor clinical outcome (p = 0.0003) (c). Kaplan-Meier survival curves demonstrating no significant difference between 10 and 15% CNV thresholds (additionally, < 10% vs 10–15% p = 0.6003; 10–15% vs > 15% p = 0.0113) (d), no significant difference between 15 and 18% CNV thresholds (< 15% vs < 18, p = 0.5949; > 15% vs > 18% p = 0.9015) (e), and no significant difference between 10 and 18% CNV thresholds (< 10% vs < 18, p = 0.4791; > 10% vs > 18% p = 0.2672) (f). Copy number variation is expressed as a percentage of the total genome, log2 > 0.3 as reported previously [10, 12]