Skip to main content

Table 1 Histopathological and molecular characteristics of the cell models

From: TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma

 HistologyBRAF V600ETERT prom. mutationTERT mRNA expressionCDKN2A expressionAdditional genetic aberrationsStable cell line
BTL1333GBM*wtwtnegposTP53(D228V*)yes
BTL53GBMwtwtposposTP53(V173M)
RB1 deletion
yes
BTL2176GBMwtC228TposnegPIK3CA(N1044K)yes
NMC-G1GBMposC228T (homozygous)posnegyes
DBTRG-05MGGBMposC228TposnegPOT1(G40*)yes
AM38GBMposC250TposnegALK(S737 L)yes
VBT92aPXA+posC228Tposnegyes
VBT125GSoposC228Tposnegyes
BTL1304GSposC228TposnegPTEN(K266E)yes
BTL2231PXA#poswtnegnegno
VBT150PXAposwtnegposn.a.no
VBT172aPXAposwtnegposn.ano
  1. * GBM = glioblastoma multiforme
  2. +aPXA = anaplastic pleomorphic xanthoastrocytoma
  3. oGS = gliosarcoma
  4. #PXA = pleomorphic xanthoastrocytoma
  5. pos positive, neg negative, wt wild-type, mut mutated, n.a. not analyzed
\