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Table 1 β-amyloid and tau lesions in mouse lemurs of the Alzheimer- (AD) and control-inoculated (CTRL) groups. β-amyloid plaques or β-amyloid angiopathy (CAA) were detected only in Alzheimer-inoculated animals. Tau lesions detected in two Alzheimer-inoculated animals (AT8, MC1 and AT100 antibodies). * correspond to two animals that were euthanized at 12 months post inoculation. AD1 displayed β-amyloid angiopathy, high Aβ1–40 and low Aβ1–42 levels. AD2 did not display angiopathy and had low Aβ1–40 and high Aβ1–42 levels

From: Encephalopathy induced by Alzheimer brain inoculation in a non-human primate

Group

Animal

β-Amyloid

Tau - AT8

Tau - MC1

Tau - AT100

AD2

265B

+ (plaques)

++

++

++

AD2

260B

+ (plaques)

++

++

++

AD1

169ABC

± (plaques)

0

0

0

AD2

190IAB

± (plaques)

0

0

0

AD1

211DBA

± (CAA)

0

0

0

CTRL

189CBD

0

0

0

0

CTRL

190IC

0

0

0

0

CTRL

169ABB

0

0

0

0

CTRL

259BB*

0

0

0

0

CTRL

213ABA*

0

0

0

0