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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Encephalopathy induced by Alzheimer brain inoculation in a non-human primate

Fig. 2

Neuronal activity alterations in Alzheimer-inoculated mouse lemurs. Evolution of EEG frequency power densities in the Alzheimer- (AD) and control- (CTRL) inoculated groups before inoculation (a), and 6 (b) and 12 (c) mpi (n = 6 per group). a EEG frequency power densities were similar in the two groups before inoculation. b At 6 mpi, the Alzheimer-inoculated group showed a lower delta frequency (0.5–4 Hz) and a higher theta frequency (4–8 Hz) than the control-inoculated group (p = 0.009 and p = 0.002, respectively, Mann-Whitney tests). c At 12 mpi, the alterations in delta frequency were maintained (p = 0.009, Mann-Whitney test). In addition, alpha (8–12 Hz), sigma (12–16 Hz), and beta (16–24 Hz) frequencies were higher in the Alzheimer-inoculated group than in the control-inoculated group (p = 0.004, p = 0.015, and p = 0.009, respectively, Mann-Whitney tests). *p < 0.05; **p < 0.01. Scatter plots display median and interquartile interval. CTRL-inoculated animals are in blue, AD1-inoculated in green and AD2-inoculated in red

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