Fig. 5From: Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitisDemyelination and axonal injury were evident at early stage of EAE while axonal loss only was seen at the late stage of EAE. a SMI31 and MBP staining in the optic nerve of EAE mice. b SMI32 and MBP staining in the optic nerve of EAE mice. c-d Quantification of MBP and SMI31 as in figure a. e Quantification of SMI32 spheroid staining as in figure b. Boxed regions from each images were magnified as shown in figures. White dash line delineated ROI. Quantification is shown as mean ± SEM. Significance was determined by two-tailed, unpaired Student’s t-test with P < 0.05 was considered as significant. *** P ≤ 0.001. N.S. = no significant difference. Scale bar =50 μmBack to article page