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Table 5 A statistical comparison of protein levels in the caudate nucleus of HD patients and non-HD individuals from the NIH NeuroBioBank

From: A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients

  Mann-Whitneya t-testb Multiple linear regressionc
Δtau314 p = 0.027 p = 0.041 p = 0.082
T-tau p = 0.00055 p = 0.0031 p = 0.038
Δtau314:T-tau p = 0.0013 p = 0.00064 p = 0.0041
GAPDH p = 0.15 p = 0.29 p = 0.29
Casp2:GAPDH p = 0.0036 p = 0.0035 p = 0.0070
  1. aThe two-tailed, unpaired Mann-Whitney test was performed
  2. bThe two-tailed, unpaired t-test with Welch’s correction was performed on the log transformed outcomes
  3. cMultiple linear regression was used to analyze the log transformed outcomes of protein levels with adjustment for age at death, sex and PMI of brain tissue harvest