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Table 3 A statistical comparison of protein levels in the prefrontal cortex (BA8/9) of HD patients and non-HD individuals from the NIH NeuroBioBank and the New York Brain Bank

From: A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients

 

Mann-Whitneya

t-testb

Multiple linear regressionc

Δtau314

p = 0.019

p = 0.035

p = 0.094

T-tau

p = 0.011

p = 0.075

p = 0.099

Δtau314:T-tau

p = 0.00082

p = 0.013

p = 0.025

GAPDH

p = 0.46

p = 0.88

p = 0.35

Casp2:GAPDH

p = 0.0078

p = 0.0030

p = 0.019

  1. aThe two-tailed, unpaired Mann-Whitney test was performed
  2. bThe two-tailed, unpaired t-test with Welch’s correction was performed on the log transformed outcomes
  3. cMultiple linear regression was used to analyze the log transformed outcomes of protein levels with adjustment for age at death, sex and PMI of brain tissue harvest