Fig. 1
From: Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia
Schematic representation of the domain architecture of the human Ubiquilin-2 gene. UBQLN2 gene is in the chromosome Xp11.21 and have only one coding exon. UBQLN2 possess a ubiquitin-like domain (UBL) domain on the N-terminal that interacts with the proteasome and a ubiquitin-associated domain (UBA) on the C-terminal required for the UPS activity. UBQLN2 gene also arbors four stress-induced protein 1 (STI-1)-like motif and a proline-rich repeat domain containing 12 PXX repeats. UBL: Ubiquitin-like domain; STI-1: Stress-induced protein 1; UBA: Ubiquitin-associated domain; HSP70: Heat-shock protein 70; Ub: Ubiquitin