Fig. 3
From: Loss of USP18 in microglia induces white matter pathology
Gradual behavioral impairment in Cx3cr1Cre:Usp18fl/fl mice. a, d Olfactory avoidance test. The time animals spent away from the odorant zone was recorded. b, e Novel object recognition. The time a mouse spent investigating a familiar (f) or novel (N) object was recorded. The object interaction ratio was defined as the difference in exploration time for the novel object divided by the exploration time for the familiar object. c, f) Rotarod. Graphed is the latency to fall off the rod during accelerating speed (4–40 r.p.m). For all three tests, performance of Usp18fl/fl and Cx3cr1Cre:Usp18fl/fl animals was compared when they had reached 4 and 8 months of age. Asterisks indicate significant differences (*P < 0.05, **P < 0.01 and ***P < 0.001, n.s. = not significant)