Table 1 Demographics and pathologic features of FTLD-TDP cases
|  | FTLD-TDP type A (n = 8) | FTLD-TDP type B (n = 8) | FTLD-TDP type C (n = 8) |
|---|---|---|---|
Demographics | |||
 Female Sex % | 1 (12.5%) | 5 (62.5%) | 4 (50.0%) |
 Age at death | 72 (60, 78) | 63 (55, 79) | 70 (65, 83) |
Clinical diagnosis | |||
 bvFTD | 3 (37.5%) | 3 (37.5%) | 1 (12.5%) |
 PPA | 1 (12.5%) | 0 | 7 (87.5%) |
 FTD-MND/ALS | 1 (12.5%) | 5 (62.5%) | 0 |
 Other | 3 (37.5%) | 0 | 0 |
Genetic findings | |||
 C9ORF72 | 1 (12.5%) | 4 (50.0%) | 0 |
 GRN | 4 (50.0%) | 0 | 0 |
Co-pathologies | |||
 Hippocampal sclerosis | 8 (100%) | 2 (25%) | 1 (12.5%) |
 Braak NFT stage | 1.0 (0.0, 2.0) | 2.0 (1.0, 3.0) | 1.5 (0.0, 3.0) |
 Thal Phases | 0.5 (0.0, 3.0) | 0.0 (0.0, 4.0) | 0.5 (0.0, 2.0) |
 Pathological results | |||
ERC/CA1/Sub | |||
 Phosphorylated TDP-43 (pTDP-43) | 2.0 (1.0, 3.0) | 2.5 (1.0, 3.0) | 3.0 (1.0, 3.0) |
 C-Terminal specie TDP-43 (cTDP-43) | 1.5 (0.5, 3.0) | 0.5 (0.0, 3.0) | 3.0 (0.5, 3.0) |
 Full length TDP-43 (nTDP-43) | 1.0 (0.5, 2.0) | 2.0 (0.0, 3.0) | 2.0 (0.0, 3.0) |
Dentate nucleus of hippocampus | |||
 Phosphorylated TDP-43 (pTDP-43) | 2.5 (1.0, 3.0) | 3.0 (2.0, 4.0) | 3.0 (2.0, 4.0) |
 C-Terminal specie TDP-43 (cTDP-43) | 2.0 (1.0, 3.0) | 2.0 (1.0, 4.0) | 3.0 (1.0, 4.0) |
 Full length TDP-43 (nTDP-43) | 1.0 (0.0, 1.0) | 1.0 (0.0, 4.0) | 1.0 (0.0, 3.0) |