Table 1 Demographical, clinical, and neuropathological characteristics of the sample by age at death
From: Alzheimer’s disease frequency peaks in the tenth decade and is lower afterwards
<75Yr (N = 41) | 75-79Yr (N = 90) | 80-84Yr (N = 238) | 85-89Yr (N = 398) | 90-94Yr (N = 386) | 95-99Yr (N = 204) | ≥100Yr (N = 63) | Total (N = 1420) | |
|---|---|---|---|---|---|---|---|---|
Female sex, No. (%) | 16 (39) | 57 (64) | 139 (58) | 251 (63) | 272 (70) | 157 (77) | 55 (87) | 947 (67) |
Education, mean (SD), years | 18 (4) | 16 (4) | 17 (4) | 16 (4) | 16 (3) | 16 (4) | 16 (3) | 16 (4) |
AD Dementia No. (%) | 5 (12) | 19 (21) | 86 (36) | 169 (42) | 191 (49) | 112 (55) | 35 (56) | 617 (43) |
Cognitive Impairment No. (%) | 13 (32) | 37 (41) | 146 (61) | 263 (66) | 288 (75) | 164 (80) | 50 (79) | 961 (68) |
Global Cognition, mean (SD) | −0.3 (1.2) | −0.4 (1.0) | −0.7 (1.2) | −0.9 (1.2) | −1.1 (1.4) | −1.2 (1.1) | −1.4 (1.1) | − 0.9 (1.2) |
Episodic Memory, mean (SD) | −0.2 (1.3) | −0.2 (1.2) | − 0.7 (1.3) | −0.9 (1.4) | − 1.1 (1.3) | − 1.3 (1.3) | − 1.3 (1.3) | − 0.9 (1.4) |
AD Diagnosis No. (%) | 6 (15) | 39 (43) | 132 (55) | 262 (66) | 275 (71) | 155 (76) | 48 (76) | 917 (65) |
Global AD Score, mean (SD) | 0.4 (0.4) | 0.6 (0.4) | 0.7 (0.4) | 0.8 (0.4) | 0.8 (0.4) | 0.8 (0.3) | 0.8 (0.3) | 0.8 (0.4) |
Amyloid load, mean (SD) | 0.8 (0.9) | 1.1 (1.1) | 1.3 (1.1) | 1.7 (1.7) | 1.8 (1.1) | 1.8 (1.0) | 1.7 (1.1) | 1.6 (1.1) |
PHF-tau tangles density, mean (SD) | 0.8 (1.7) | 1.0 (1.3) | 1.4 (1.4) | 1.7 (1.3) | 1.7 (1.2) | 1.7 (1.1) | 1.7 (0.9) | 1.6 (1.3) |
Macroscopic infarcts, No. (%) | 5 (12) | 21 (23) | 70 (29) | 135 (34) | 150 (39) | 82 (40) | 34 (54) | 497 (35) |
Microscopic infarcts, No. (%) | 12 (29) | 20 (22) | 69 (29) | 97 (24) | 131 (34) | 67 (33) | 30 (48) | 426 (30) |
Cortical Lewy bodies, No. (%) | 4 (10) | 5 (6) | 28 (12) | 55 (14) | 54 (14) | 25 (13) | 7 (11) | 178 (13) |
TDP-43 inclusions, No. (%) | 1 (4) | 7 (9) | 35 (21) | 110 (33) | 129 (37) | 89 (46) | 29 (50) | 400 (33) |
Hippocampal sclerosis No. (%) | 1 (3) | 3 (3) | 12 (5) | 29 (7) | 43 (11) | 27 (13) | 12 (19) | 127 (9) |
APOE ε4 carriers, No. (%) | 9 (22) | 25 (29) | 82 (35) | 113 (29) | 92 (24) | 44 (22) | 8 (13) | 373 (27) |