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Table 1 Demographical, clinical, and neuropathological characteristics of the sample by age at death

From: Alzheimer’s disease frequency peaks in the tenth decade and is lower afterwards

  <75Yr (N = 41) 75-79Yr (N = 90) 80-84Yr (N = 238) 85-89Yr (N = 398) 90-94Yr (N = 386) 95-99Yr (N = 204) ≥100Yr (N = 63) Total (N = 1420)
Female sex, No. (%) 16 (39) 57 (64) 139 (58) 251 (63) 272 (70) 157 (77) 55 (87) 947 (67)
Education, mean (SD), years 18 (4) 16 (4) 17 (4) 16 (4) 16 (3) 16 (4) 16 (3) 16 (4)
AD Dementia No. (%) 5 (12) 19 (21) 86 (36) 169 (42) 191 (49) 112 (55) 35 (56) 617 (43)
Cognitive Impairment No. (%) 13 (32) 37 (41) 146 (61) 263 (66) 288 (75) 164 (80) 50 (79) 961 (68)
Global Cognition, mean (SD) −0.3 (1.2) −0.4 (1.0) −0.7 (1.2) −0.9 (1.2) −1.1 (1.4) −1.2 (1.1) −1.4 (1.1) − 0.9 (1.2)
Episodic Memory, mean (SD) −0.2 (1.3) −0.2 (1.2) − 0.7 (1.3) −0.9 (1.4) − 1.1 (1.3) − 1.3 (1.3) − 1.3 (1.3) − 0.9 (1.4)
AD Diagnosis No. (%) 6 (15) 39 (43) 132 (55) 262 (66) 275 (71) 155 (76) 48 (76) 917 (65)
Global AD Score, mean (SD) 0.4 (0.4) 0.6 (0.4) 0.7 (0.4) 0.8 (0.4) 0.8 (0.4) 0.8 (0.3) 0.8 (0.3) 0.8 (0.4)
Amyloid load, mean (SD) 0.8 (0.9) 1.1 (1.1) 1.3 (1.1) 1.7 (1.7) 1.8 (1.1) 1.8 (1.0) 1.7 (1.1) 1.6 (1.1)
PHF-tau tangles density, mean (SD) 0.8 (1.7) 1.0 (1.3) 1.4 (1.4) 1.7 (1.3) 1.7 (1.2) 1.7 (1.1) 1.7 (0.9) 1.6 (1.3)
Macroscopic infarcts, No. (%) 5 (12) 21 (23) 70 (29) 135 (34) 150 (39) 82 (40) 34 (54) 497 (35)
Microscopic infarcts, No. (%) 12 (29) 20 (22) 69 (29) 97 (24) 131 (34) 67 (33) 30 (48) 426 (30)
Cortical Lewy bodies, No. (%) 4 (10) 5 (6) 28 (12) 55 (14) 54 (14) 25 (13) 7 (11) 178 (13)
TDP-43 inclusions, No. (%) 1 (4) 7 (9) 35 (21) 110 (33) 129 (37) 89 (46) 29 (50) 400 (33)
Hippocampal sclerosis No. (%) 1 (3) 3 (3) 12 (5) 29 (7) 43 (11) 27 (13) 12 (19) 127 (9)
APOE ε4 carriers, No. (%) 9 (22) 25 (29) 82 (35) 113 (29) 92 (24) 44 (22) 8 (13) 373 (27)
  1. AD denotes Alzheimer’s Disease