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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model

Fig. 4

ACY-738 therapy reduces neuromuscular denervation and muscle atrophy in Tg FUS+/+ mice. a Number of α-motor neurons in the lumbar spinal cord of P40 and P60 vehicle- and ACY-738-treated Tg FUS+/+ mice. n = 4–9, Student’s t-test. b Percentage of innervated neuromuscular junctions in the gastrocnemius muscle of P40 and P60 vehicle- and ACY-738-treated Tg FUS+/+ mice. At least 50 neuromuscular junctions were counted per mouse. n = 4–6, Student’s t-test. c Weight of gastrocnemius muscle of P40 and P60 vehicle- and ACY-738-treated Tg FUS+/+ mice. n = 6–10, Student’s t-test. d Representative picture of muscle fibers of the gastrocnemius muscle P60 vehicle- and ACY-738-treated Tg FUS+/+ mice. Scale bar = 100 μm. (e) Muscle fiber area distribution of the gastrocnemius muscle of P40 and P60 vehicle- and ACY-738-treated Tg FUS+/+ mice. n = 3–4, Two-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05, **P < 0.01, ***P < 0.001 ****P < 0.0001. Data are presented as means ± SEM

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