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Table 2 Cox proportional hazards models in Step 2

From: Distribution differences in prognostic copy number alteration profiles in IDH-wild-type glioblastoma cause survival discrepancies across cohorts

  Univariate Multivariate
HR 95% CI for HR p-value HR 95% CI for HR p-value
Cohort K2 (n = 140)
 Agea 1.027 1.009–1.047 0.002 1.035 1.016–1.056 < 0.001
 KPS ≤70% 1.611 1.082–2.391 0.019 excluded by factor selection with step-wise method
≥80% Ref
 Extent of resection < 90% 1.555 1.051–2.310 0.027 1.860 1.246–2.790 0.002
≥90% Ref Ref   
 MGMT promoter Un-Met 2.037 1.351–3.123 < 0.001 2.447 1.601–3.808 < 0.001
Met Ref Ref   
 PTEN Del 1.552 1.041–2.314 0.031 excluded by factor selection with step-wise method
Neutral Ref
 NFKBIA Del 1.613 1.016–2.490 0.043 1.886 1.181–2.930 0.009
Neutral Ref Ref   
 Triple CNA Triple 2.134 1.348–3.303 0.002 2.361 1.475–3.702 < 0.001
Non-triple Ref Ref   
Cohort T2 (n = 152)
 Agea 1.023 1.005–1.041 0.009 excluded by factor selection with step-wise method
 MGMT Un-Met 2.316 1.419–3.855 < 0.001 2.320 1.422–3.860 < 0.001
Met Ref    Ref   
 NFKBIA Del 1.767 1.118–2.735 0.016 excluded by factor selection with step-wise method
Neutral Ref   
 Triple CNA Triple 1.576 1.027–2.489 0.037 1.736 1.053–2.980 0.030
Non-triple Ref    Ref   
  1. Abbreviations: CI confidence interval, Del homozygous and/or hemizygous deletion, Met methylated, Ref Reference: aHR is for each 1 year increase. Statistically significant (p < 0.05)