Distribution differences in prognostic copy number alteration profiles in IDH-wild-type glioblastoma cause survival discrepancies across cohorts

Table 2 Cox proportional hazards models in Step 2

		Univariate			Multivariate
		HR	95% CI for HR	p-value	HR	95% CI for HR	p-value
Cohort K2 (n = 140)
Age^a		1.027	1.009–1.047	0.002^†	1.035	1.016–1.056	< 0.001^†
KPS	≤70%	1.611	1.082–2.391	0.019^†	excluded by factor selection with step-wise method
KPS	≥80%	Ref	–	–	excluded by factor selection with step-wise method
Extent of resection	< 90%	1.555	1.051–2.310	0.027^†	1.860	1.246–2.790	0.002^†
Extent of resection	≥90%	Ref	–	–	Ref
MGMT promoter	Un-Met	2.037	1.351–3.123	< 0.001^†	2.447	1.601–3.808	< 0.001^†
MGMT promoter	Met	Ref	–	–	Ref
PTEN	Del	1.552	1.041–2.314	0.031^†	excluded by factor selection with step-wise method
PTEN	Neutral	Ref	–	–	excluded by factor selection with step-wise method
NFKBIA	Del	1.613	1.016–2.490	0.043^†	1.886	1.181–2.930	0.009^†
NFKBIA	Neutral	Ref	–	–	Ref
Triple CNA	Triple	2.134	1.348–3.303	0.002^†	2.361	1.475–3.702	< 0.001^†
Triple CNA	Non-triple	Ref	–	–	Ref
Cohort T2 (n = 152)
Age^a		1.023	1.005–1.041	0.009^†	excluded by factor selection with step-wise method
MGMT	Un-Met	2.316	1.419–3.855	< 0.001^†	2.320	1.422–3.860	< 0.001^†
MGMT	Met	Ref			Ref
NFKBIA	Del	1.767	1.118–2.735	0.016^†	excluded by factor selection with step-wise method
NFKBIA	Neutral	Ref			excluded by factor selection with step-wise method
Triple CNA	Triple	1.576	1.027–2.489	0.037^†	1.736	1.053–2.980	0.030^†
Triple CNA	Non-triple	Ref			Ref

Abbreviations: CI confidence interval, Del homozygous and/or hemizygous deletion, Met methylated, Ref Reference: ^aHR is for each 1 year increase. ^†Statistically significant (p < 0.05)

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