|
Univariate
|
Multivariate
|
---|
HR
|
95% CI for HR
|
p-value
|
HR
|
95% CI for HR
|
p-value
|
---|
Cohort K2 (n = 140)
|
Agea
|
1.027
|
1.009–1.047
|
0.002†
|
1.035
|
1.016–1.056
|
< 0.001†
|
KPS
|
≤70%
|
1.611
|
1.082–2.391
|
0.019†
|
excluded by factor selection with step-wise method
|
≥80%
|
Ref
|
–
|
–
|
Extent of resection
|
< 90%
|
1.555
|
1.051–2.310
|
0.027†
|
1.860
|
1.246–2.790
|
0.002†
|
≥90%
|
Ref
|
–
|
–
|
Ref
| | |
MGMT promoter
|
Un-Met
|
2.037
|
1.351–3.123
|
< 0.001†
|
2.447
|
1.601–3.808
|
< 0.001†
|
Met
|
Ref
|
–
|
–
|
Ref
| | |
PTEN
|
Del
|
1.552
|
1.041–2.314
|
0.031†
|
excluded by factor selection with step-wise method
|
Neutral
|
Ref
|
–
|
–
|
NFKBIA
|
Del
|
1.613
|
1.016–2.490
|
0.043†
|
1.886
|
1.181–2.930
|
0.009†
|
Neutral
|
Ref
|
–
|
–
|
Ref
| | |
Triple CNA
|
Triple
|
2.134
|
1.348–3.303
|
0.002†
|
2.361
|
1.475–3.702
|
< 0.001†
|
Non-triple
|
Ref
|
–
|
–
|
Ref
| | |
Cohort T2 (n = 152)
|
Agea
|
1.023
|
1.005–1.041
|
0.009†
|
excluded by factor selection with step-wise method
|
MGMT
|
Un-Met
|
2.316
|
1.419–3.855
|
< 0.001†
|
2.320
|
1.422–3.860
|
< 0.001†
|
Met
|
Ref
| | |
Ref
| | |
NFKBIA
|
Del
|
1.767
|
1.118–2.735
|
0.016†
|
excluded by factor selection with step-wise method
|
Neutral
|
Ref
| | |
Triple CNA
|
Triple
|
1.576
|
1.027–2.489
|
0.037†
|
1.736
|
1.053–2.980
|
0.030†
|
Non-triple
|
Ref
| | |
Ref
| | |
- Abbreviations: CI confidence interval, Del homozygous and/or hemizygous deletion, Met methylated, Ref Reference: aHR is for each 1 year increase. †Statistically significant (p < 0.05)