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Table 1 Comparison of molecular and clinical characteristics of patients with IDH-wild-type GBM

From: Distribution differences in prognostic copy number alteration profiles in IDH-wild-type glioblastoma cause survival discrepancies across cohorts

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Cohort K1 (n = 212) Cohort T1 (n = 359) Cohort K2 (n = 140) Cohort T2 (n = 152)
Clinical status Age (years) at diagnosis Median (range) 67.0 (18–93) 61.0 (18–89) 64.0 (18–82) 59.0 (18–86)
elderly (≥65) 125 (59.0%) 138 (38.4%) 67 (47.9%) 41 (27.0%)
Gender Male 114 (53.8%) 221 (61.6%) 77 (55.0%) 93 (61.2%)
Female 98 (46.2%) 138 (38.4%) 63 (45.0%) 59 (38.8%)
Preoperative KPS (%) 80–100 99 (47.4%) 195 (71.2%) 79 (56.4%) 100 (79.4%)
0–70 110 (52.6%) 79 (28.8%) 61 (43.6%) 26 (20.6%)
N/A 3 85 0 26
Extent of resection ≥ 90% 104 (49.8%) 68 (48.6%)
N/A 3 0
TERT promoter Mut 125 (59.0%) 81 (57.9%)
N/A 0 0
MGMT promoter Met 98 (46.2%) 110 (41.5%) 59 (42.1%) 56 (44.8%)
N/A 0 94 0 27
TP53 Mut 80 (37.7%) 60 (26.7%) 53 (37.9%) 22 (24.4%)
N/A 0 134 0 62
CNA PDGFRA Amp 33 (15.6%) 53 (14.8%) 20 (14.3%) 19 (12.5%)
Gain 10 (4.7%) 20 (5.6%) 8 (5.7%) 11 (7.2%)
EGFR Amp 54 (25.5%) 181 (50.4%) 39 (27.9%) 76 (50.0%)
Gain 65 (30.7%) 159 (44.3%) 39 (27.9%) 67 (44.1%)
CDKN2A Homo 79 (37.3%) 210 (58.5%) 58 (41.4%) 87 (57.2%)
Hemi 53 (25.0%) 61(17.0%) 30 (21.4%) 23 (15.1%)
PTEN Homo 4 (1.9%) 41 (11.4%) 3 (2.1%) 14 (9.2%)
Hemi 90 (42.5%) 300 (83.6%) 58 (41.4%) 132 (86.8%)
CDK4 Amp 23 (10.8%) 57 (15.9%) 13 (9.3%) 19 (12.5%)
Gain 7 (3.3%) 33 (9.2%) 7 (5.0%) 17 (11.2%)
MDM2 Amp 18 (8.5%) 33 (9.2%) 10 (7.1%) 12 (7.9%)
Gain 3 (1.4%) 28 (7.8%) 3 (2.1%) 15 (9.9%)
NFKBIA Homo 1 (0.5%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
Hemi 46 (21.7%) 109 (30.4%) 33 (23.6%) 45 (29.6%)
TP53 Homo 8 (3.8%) 6 (1.7%) 5 (3.6%) 3 (2.0%)
Hemi 78 (36.8%) 56 (15.6%) 50 (35.7%) 22 (14.5%)
Mut/Del 122 (57.5%) 96 (38.6%) 80 (57.1%) 39 (38.6%)
Triple CNA Triple 51 (24.1%) 253 (70.5%) 34 (24.3%) 103 (67.8%)
Non triple 161 (75.9%) 106 (29.5%) 106 (75.7%) 49 (32.2%)
  1. Abbreviations: Amp Amplification, Del homozygous and/or hemizygous deletion, Hemi hemizygous deletion, Homo homozygous deletion, Met methylated, Mut mutated, Mut/Del Mut or Del, N/A not available