Fig. 1

Photos of immunohistochemically (IHC) stained sections of brain biopsies from the frontal cortex. In a-d, the IHC outcome when applying antibodies directed to the β-amyloid (Aβ) and in E-H applying hyperphosphorylated τ protein (HPτ). In b, d, f, and h, the results of positive pixel count analysis, where negative pixels are blue, weak stained positive pixels are yellow, moderately stained pixels are orange, and strong positive pixels are brown. In a-b, Aβ extent in a case with stained area fraction (SAF) of 1%; in C-D Aβ extent SAF 27%; E-F HPτ extent SAF 0.05% and in G-H HPτ extent SAF 19%. Bar 50 μm