Table 2 Summary of mutations in genes with known functions related to maintaining DNA and chromosomal stability for each group
From: Total copy number variation as a prognostic factor in adult astrocytoma subtypes
Group | Tumor Type | Mutations in genes with functions related to maintaining |
|---|---|---|
overall genome/chromosomal stability | ||
1 | IDH-mut LGG | BRCA2 |
2 | IDH-mut CDK4/ | Â |
CDKN2A/B LGG | APC, ATM, FANCB, FANCD2, RAD51 (2), TOP1 | |
3 | IDH-mut GBM | APC (4), BLM, BRCA2, SMC1 (2) |
4 | IDH-wt LGG | BLM, FANCB (2), FANCE, LIG4 |
5 | IDH-wt GBM | ATR, BRCA2 (2), CLSPN, FANCI (2), FANCM (2), PRKDC, REV3 |