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Table 2 Summary of mutations in genes with known functions related to maintaining DNA and chromosomal stability for each group

From: Total copy number variation as a prognostic factor in adult astrocytoma subtypes

Group Tumor Type Mutations in genes with functions related to maintaining
overall genome/chromosomal stability
1 IDH-mut LGG BRCA2
2 IDH-mut CDK4/  
CDKN2A/B LGG APC, ATM, FANCB, FANCD2, RAD51 (2), TOP1
3 IDH-mut GBM APC (4), BLM, BRCA2, SMC1 (2)
4 IDH-wt LGG BLM, FANCB (2), FANCE, LIG4
5 IDH-wt GBM ATR, BRCA2 (2), CLSPN, FANCI (2), FANCM (2), PRKDC, REV3