From: Total copy number variation as a prognostic factor in adult astrocytoma subtypes
Group | Tumor Type | n | Age at Onset (years) | Median Progression-Free Survival (months) | Median Overall Survival (months) | Histologic Grade (II/III/IV) | CNV Level (%) | Cases with Chromothripsis | Mutation Count | Instability Gene Mutations |
---|---|---|---|---|---|---|---|---|---|---|
1 | IDH-mut LGG | 24 | 38.8 ± 1.9 | 95 | > 172 | 12/12/0 | 9.1 ± 1.6 | 2 (8.3%) | 43 ± 10.5 | 1 (4.1%) |
2 | IDH-mut CDK4/ | Â | Â | Â | Â | Â | Â | Â | Â | Â |
CDKN2A/B LGG | 22 | 38.8 ± 1.9 | 32 | 36 | 4/18/0 | 21.3 ± 2.5 | 6 (27.3%) | 33.3 ± 1.3 | 7 (31.8%) | |
3 | IDH-mut GBM | 22 | 40.5 ± 2.7 | 10 | 33 | 0/0/22 | 20 ± 2.7 | 9 (40.9%) | 67.4 ± 2.75 | 8 (36.4%) |
4 | IDH-wt LGG | 25 | 54.0 ± 2.6 | 10.5 | 15.5 | 0/25/0 | 19.9 ± 1.8 | 5 (20.0%) | 64.9 ± 16.7 | 5 (20.0%) |
5 | IDH-wt GBM | 42 | 62.8 ± 1.7 | 6 | 13 | 0/0/42 | 22.2 ± 1.6 | 11 (26.2%) | 57.0 ± 2.5 | 10 (23.8%) |