Fig. 4

Hyper- and hypo-methylation in two independent cohorts (TCGA and ‘Australian’). a Heatmap of DNA methylation levels measured as beta values: hierarchical clustering was performed for both of samples (columns) and the sites (rows) either hyper- or hypo-methylation identified in the discovery cohort (“SNU”). The color gradients from blue to red correspond to beta values from 0 to 1. b Summary scores in terms of hyper- and hypo-methylation for each sample in two test cohorts: Each sample, denoted by a dot is assigned to two simple arithmetic averages (x and y axes values) of beta values in hyper- and hypo- methylation sites. The dashed line indicates 0.2 as a decision threshold for LTS-GBM