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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma

Fig. 3

Functional implication of hyper- and hypo-methylated sites in LTS-GBM. a Distribution of Pearson correlation coefficients between DNA methylation level (beta) and gene expression measured by RNA-seq (FPKM) across 32 GBM samples in TCGA. The red describes the genes (number of genes: 366) corresponding to the selected hyper-methylated sites in this study while the gray shows the genes (number of genes: 4413) matched to insignificant sites associated with the island. b DNA methylation level around somatic mutations found in 136 TCGA GBM samples by whole exome sequencing. The hypo-methylated sites in LTS-GBM (N = 1802) were compared with the insignificant sites in open sea (N = 5032)

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