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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma

Fig. 2

Enrichment of differentially-methylated sites in regulatory histone marks. a Enrichment patterns of differentially-methylated sites with histone marks. For a given histone mark (x axis), Y axis value describes the differences of enrichment proportion between the significantly- differential methylation sites and the insignificant sites. The red denotes hypermethylated sites in island while the blue describes hypomethylated sites in open sea. The size of dot indicates the range of enrichment proportion of the significantly- differential sites. We grouped the proportion to 4 regions for clear visualization (4 dot sizes): 0~0.25, 0.25~0.5, 0.5~0.75, 0.75~1. b The relation between the ChIP-seq signal of H3K27ac and the DNA methylation level (beta) for the hyper-methylated sites in U87MG cell line. Each dot denotes the site. c The same plot as (b) for the hyper-methylated sites in H1 cell line

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