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Table 3 Neuropathologic characteristics by resistance and resilience status

From: Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

Pathology
(mean+/− SD)
Resistant
(n = 14)
AD Dementia Matched to Resistant
(n = 14)
p value Resilient
(n = 7)
AD Dementia Matched to Resilient
(n = 7)
p value
Brain Weight (grams) 1228 (75) 1115 (84) 0.001 1223 (151) 1120 (205) 1.128
Thal Phase 0.64 (0.50) 4.57 (0.51) ND 4.33 (0.52) 4.86 (0.38) ND
Braak Stage 3.36 (0.74) 5.79 (0.43) ND 5.86 (0.38) 5.86 (0.38) ND
CERAD score 0.07 (0.27) 3.00 (0.0) ND 3.00 (0.0) 3.00 (0.0) ND
Atherosclerosis 1.93 (0.62) 2.29 (0.50) 0.097 1.86 (1.10) 1.57 (0.53) 0.421
Arteriolosclerosis 2.00 (0.68) 2.57 (0.51) 0.031 2.14 (0.38) 2.29 (0.76) 0.655
Macroinfarcts 0.50 (0.85) 0.57 (0.76) 0.895 0 (0) 0.86 (1.07) 0.048
Microinfarcts 1.07 (1.27) 1.50 (1.23) 0.356 0.57 (1.13) 1.14 (1.07) 0.389
CAA severity (OC) 0.50 (0.85) 1.36 (0.84) 0.015 1.86 (1.35) 1.42 (0.79) 0.252
Lewy body distribution 1.00 (1.57) 1.50 (1.83) 0.388 0 (0) 0.57 (1.51) 0.317
LATE-NC 0.21 (0.58) 2.40 (0.94) 0.0009 0.43 (1.13) 1.86 (0.90) 0.047
  1. Wilcoxon matched-pairs signed-ranks test; ND, Not Done; LATE-NC, limbic-predominant age-related TDP-43 encephalopathy neuropathologic change. Bold values indicate statistical significance