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Table 2 Clinical characteristics by resistance and resilience status

From: Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

  Resistant
(n = 14)
AD Dementia Matched to Resistant
(n = 14)
p value Resilient
(n = 7)
AD Dementia Matched to Resilient
(n = 7)
p value
Age at death (years)
mean (SD)
94.7 (3.8) 94.5 (2.5) 0.47 85.2 (6.1) 86.7 (3.5) 0.31
Sex - female
n (%)
8 (57.1) 8 (57.1) 1.00 5 (71.4) 5 (71.4) 1.00
Education (years)
mean (SD)
15.1 (3.1) 13.2 (2.6) 0.10 15.9 (2.7) 15.4 (3.7) 0.67
APOE, n (%)
ε2/2 allele
0 (0.0) 2 (14.3)   0 (0.0) 0 (0.0)  
ε2/3 allele 2 (14.3) 0 (0.0)   1 (14.3) 0 (0.0)  
ε3/3 allele 11 (78.6) 5 (35.7)   4 (57.1) 2 (33.3)  
ε2/4 allele 0 (0.0) 0 (0.0)   0 (0.0) 1 (16.7)  
ε3/4 allele 1 (7.1) 7 (50.0)   2 (28.6) 3 (50.0)  
1 copy of ε4 allele
n (%)
1 (7.1) 7 (50.0) 0.03 2 (28.6) 4 (66.7) 0.50
Age at final study visit (years)
mean (SD)
93.1 (3.9) 87.4 (3.7) < 0.001 83.9 (5.6) 79.7 (5.5) 0.05
CASI to death (years)
mean (SD)
1.0 (0.6) 6.8 (2.8) 0.001 0.9 (0.5) 7.0 (3.4) 0.03
Charlson Comorbidity Index (cumulative) mean (SD) 2.2 (1.9) 2.1 (2.0) 0.90 3.4 (2.6) 1.1 (1.3) 0.06
Smoking (cumulative pack years)
mean (SD)
14.0 (21.1) 14.8 (16.3) 0.43 19.3 (21.6) 4.6 (9.6) 0.15
  1. Wilcoxon matched-pairs signed-ranks test. Note: Cumulative measures were based on self-report at the last ACT study visit attended. Participants diagnosed with dementia were administratively censored from ACT, whereas dementia-free participants continued with biennial study visits. Bold values indicate statistical significance