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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

Fig. 8

Synaptic integrity of the perforant pathway in the resilient group. The ratio of synaptophysin staining between the outer molecular layer of the dentate gyrus of the hippocampus (red asterisk) and the inner molecular layer (black asterisk) provides a measure of synaptic integrity of the perforant pathway. The AD dementia subjects had a reduced ratio due to a preferential reduction in staining of the outer molecular layer compared to the inner layer while the resilient group maintained a ratio closer to one, reflecting maintained synaptic health. *p < 0.05, Wilcoxon matched-pairs signed-ranks test

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