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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

Fig. 4

Semi-quantification of pathologic proteins. The burden of each pathologic protein (Aβ, pTau, and pTDP-43) was assessed in each subject by assigning a score of 0–3 for Aβ, 0–3 for pTau and 0–6 for pTDP-43. a As expected (based on selection criteria), the resistant group had very little pathology resulting in significant differences for each pathologic protein in nearly every brain region assessed compared to the AD dementia matches. b The resilient group showed no significant differences in burden of Aβ pathology throughout the cortex, but did show significantly lower Aβ in midbrain and cerebellum. pTau pathology was significantly less only in the MFG in resilient cases. pTDP-43 pathology showed significantly less pathologic burden in the AMY and HPC. (MFG, middle frontal gyrus, IPL, inferior parietal lobule; MTG, middle temporal gyrus; STG, superior temporal gyrus; OC, occipital cortex; STR, striatum; MB, midbrain; CBL, cerebellum; HPC, hippocampus; AMY, amygdala) ***p < 0.005, **p < 0.01, *p < 0.05; Wilcoxon matched-pairs signed-ranks test

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