Fig. 3

Neuropathology Summary Score. Every subject is depicted by a bar, which is subdivided by colors to represent the different types of neuropathology present for each subject. The grey bars represent AD neuropathologic change (ADNC) and are calculated as (Braak stage/2) + CERAD score, such that the maximum score for ADNC is 6. The slate bars represent microvascular brain injury (μVBI), specifically the microinfarct burden, such that 1 microinfarct = 1, 2 microinfarcts = 2, and 3 or more microinfarcts = 3. The black bars represent extent of Lewy body disease (LBD), such that 1 = brainstem only, 2 = limbic/amygdala predominant, 3 = neocortical. The red bars represent limbic-predominant age-related TDP-43 neuropathologic change (LATE-NC), such that 1 = amygdala only, 2 = hippocampal, and 3 = neocortical (beyond medial temporal). Overall, the resistant and resilient groups conspicuously lack LATE-NC, while pTDP-43 pathology is nearly ubiquitously present in subjects with dementia