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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity

Fig. 5

DLK inhibition can partially prevent the age-related loss of connectivity in culture. a Connectivity score map showing that chronic treatment with 0.01 μM GNE3511 could prevent the age-related loss of connectivity. Other effects were not lasting or neurotoxic (Morph.: nbio = 1 x ntech = 6 - Func.: nbio = 1 x ntech = 9); b Z-scores of example descriptors (Morph.: nbio = 1 x ntech = 6 - Func.: nbio = 1 x ntech = 9)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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