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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism

Fig. 3

c-MYC is expressed in a proportion of human CPTs. a Unsupervised hierarchical clustering analysis of 356 genes, the expression of which significantly correlated with c-MYC expression in 40 CPTs from Merino et al. dataset, showing clustering of CPTs based on c-MYC expression. The heat map colour for each tumour is defined by the Pearson correlation coefficient between the log-ratio expression profiles of genes. b-g Representative histology of the analysis of an independent (Brain UK) cohort of human CPT: papilloma, WHO grade I (b CPP), atypical papilloma WHO grade II (c ACPP) and carcinoma, WHO grade III (d CPC). e-f c-MYC immunohistochemistry showing mostly diffuse expression (e) and in some cases focal expression (f). Nuclear expression of c-MYC in more than 10% was considered as positive. g Graphical representation of cases positive for c-MYC, overall and among different histological subtypes. 18/42 (43%) of all cases were c-MYC positive; 4/6 (67%) CPC, 6/12 (50%) ACPP and 8/24 (33%) CPP were c-MYC positive. Scale bar = 125 μm (b, c, d, e, f)

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