Skip to main content
Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism

Fig. 1

CPT develop at high penetrance in NestinCre;STOPFloxc-MYC mice. a Schematic of generation of double transgenic NestinCre;STOPfloxc-MYC mice. b CPT arising in a double transgenic mouse, with a tumour seen within the lateral ventricle (left) as compared to normal choroid plexus in the fourth ventricle (centre). c A large proportion (84.2%) of compound mice developed CPT (pie graph on the left); the majority of them (81.3%) were CPP, whist the rest (18.8%) were ACPP, (graph on the right). d GFP immunohistochemistry showing strong and even expression in the CPT as compared to control CP (inset). e-h H&E of CPT. CPP shows mild stratification of cells albeit with largely preserved papillary architecture and with mild cellular and nuclear pleomorphism (e low magnification; g high magnification) while ACPP showed moderate cellular and nuclear pleomorphism with more blunting of papillary architecture (f low magnification and h high magnification). In addition ACPPs showed significantly higher Ki-67 labelling as compared to CPPs (i CPP; j ACPP). k Ki67 quantification (Bar graph representing average cells/HPF as mean ± SEM, n = 3 in each cohort, * P < 0.05). Scale bar = 1 mm (b), 250 μm (d, e, f) and 125 μm (g, h, i, j). Abbreviations: CP – choroid plexus; CPT-choroid plexus tumour; ACPP – atypical choroid plexus tumour; CPP – choroid plexus papilloma; NSPCs – neural stem progenitor cells; H&E – haematoxylin and eosin; GFP – Green Fluorescent Protein, indicative of c-MYC expression

Back to article page