Fig. 1

Transcriptome profiling of neural stem cells of the human SVZ. a Scheme of experimental set-up. b PCA plot showing distribution of SVZ and CD271⁺ NSCs from both control and PD donors. c Differentially expressed genes (in red) visualized in an MA plot for CD271⁺ cells vs SVZ cells from control donors (p-value < 0.01, adj p-value < 0.01). d Panther pathway analysis of differentially expressed genes between CD271⁺ cells and SVZ cells (p-value < 0.05). e Panther pathway analysis of genes upregulated in CD271⁺ cells when compared to SVZ homogenate (p-value < 0.05). f PCA plot showing the distribution of CD271⁺ cells and CD11b⁺ cells. g MA plot showing differentially expressed genes (in red) between CD271⁺ cells and CD11b⁺ cells. CTRL = control; PD = Parkinson’s disease